Abstract:

Maximizing value and minimizing waste in clinical trial research in swine: Selecting interventions to build an evidence base

Jan M. Sargeant, DVM, PhD, FCAHS; Annette M. O’Connor, BVSc, DVSc, FANZCVS; Terri L. O’Sullivan, DVM, PhD; Alejandro Ramirez, DVM, MPH, PhD, DACVPM

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Researchers conduct a trial to compare an intervention of interest to a comparison group. Initially, researchers should determine whether a trial is evaluating superiority, equivalence, or noninferiority. This decision will guide the choice of a placebo versus active comparison group. Interventions, as well as baseline management, should be comprehensively reported to allow replication or clinical application. It is necessary to build a body of evidence across multiple trials to apply evidence-based decision-making. To achieve this, at least one intervention in every trial should be an intervention that has been used in at least one previously published trial.

Keywords: clinical trial, evidence, interventions, linking networks

Cite as: Sargeant JM, O’Connor AM, O’Sullivan TL, Ramirez A. Maximizing value and minimizing waste in clinical trial research in swine: Selecting interventions to build an evidence base. J Swine Health Prod 2022;30(6):355-361.

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