A new vaccine developed by scientists with the U.S. Department of Agriculture’s Agricultural Research Service (ARS), the Department of Homeland Security (DHS) and a U.S. biopharmaceutical company holds promise for protection against foot-and-mouth disease which strikes cattle and swine, as well as sheep, goats and deer.
The new vaccine works quickly, demonstrating effectiveness within seven days. Tests thus far have shown that vaccinated cattle retain immunity for at least 21 days, but scientists expect that future studies will show that the new vaccine at least matches the six months of immunity provided by current vaccines. The new vaccine has been tested on cattle and swine, and is equally effective in both species.
The vaccine is the first molecular-based FMD vaccine for cattle, developed by scientists with ARS, the Department of Homeland Security’s Targeted Advanced Development unit (TAD) and GenVec, Inc., a biopharmaceutical company based in Gaithersburg, Md. Additional testing is examining the vaccine’s commercial viability and effectiveness against the various serotypes of FMD virus.
The new vaccine has many benefits. It is administered in a nonreplicating adenovirus. It does not require expensive, high-containment production facilities, and it can be produced safely in the United States because it can be made without using infectious FMD materials.
In addition, the vaccine also makes it possible for scientists to determine whether an animal found to have FMD antibodies acquired them through vaccination or from infection–an important piece of information because of the trade restrictions associated with using current vaccines.
Source:
ARS