TY - JOUR AU - Charles, SD AU - Abraham, AS AU - Trigo, ET TI - Reduced shedding and clinical signs of Salmonella Typhimurium in nursery pigs vaccinated with a Salmonella Choleraesuis vaccine T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2000/May// PY - 2000 VL - 8 M1 - 3 IS - 3 M2 - 107 SP - 107-112 L2 - https://www.aasv.org/shap/issues/v8n3/v8n3p107.html UR - https://www.aasv.org/shap/abstracts/abstract.php?v8n3p107 L1 - https://www.aasv.org/shap/issues/v8n3/v8n3p107.pdf KW - swine KW - Salmonella KW - vaccine KW - Salmonella serotype Typhimurium; Salmonella serotype Choleraesuis N2 - Objective: To determine whether vaccination with a modified-live Salmonella serotype Choleraesuis vaccine can protect pigs 3 weeks of age or older against infection caused by Salmonella serotype Typhimurium.Methods: Three studies were conducted using 3- to 4-week-old crossbred pigs. The studies differed in the number of times the vaccine was administered (twice in Study One, once in Studies Two and Three), the severity of the challenge (1 x 1010 in Studies One and Two, 1 x 106 in Study Three), and the principle variables recorded during the study (clinical disease in Studies One and Two, shedding and isolation of the challenge organism in feces and tissues in Studies One and Three). In each study, pigs in a VACC-CHAL group were vaccinated orally (individually in Study One or with a water proportioner in Studies Two and Three) at 3 weeks of age and challenged 3 weeks later with virulent Salmonella Typhimurium. CHAL pigs were challenged but not vaccinated, and Control pigs were neither vaccinated nor challenged. Pigs were weighed and their temperatures were taken; they were scored for clinical signs of disease and for fecal consistency; and fecal, serum, and necropsy samples were taken for culture and ELISA.Results: A significant difference in average percent healthy pigs, increased average daily gains, and lower rectal temperatures were observed in the VACC-CHAL pigs compared to CHAL pigs in Studies One and Two. Vaccinated pigs shed Salmonella Typhimurium for significantly fewer days than the CHAL pigs, and Salmonella Typhimurium was recovered from significantly more tissues and in greater numbers from nonvaccinated pigs than from the vaccinated pigs in Study Three.Implications: A Salmonella Choleraesuis vaccine can aid in preventing disease and reduce the shedding and colonization of Salmonella Typhimurium in pigs >=3 weeks of age. ER -