TY - JOUR AU - Vilalta, C AU - Alcalá, T AU - López-Jimenez, R TI - Clinical efficacy of acetylsalicylic acid as an adjunct to antibacterial treatment of porcine respiratory disease complex T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2012/Jan// PY - 2012 VL - 20 M1 - 1 IS - 1 M2 - 10 SP - 10-16 L2 - https://www.aasv.org/shap/issues/v20n1/v20n1p10.html UR - https://www.aasv.org/shap/abstracts/abstract.php?v20n1p10 L1 - https://www.aasv.org/shap/issues/v20n1/v20n1p10.pdf KW - swine KW - acetylsalicylic acid KW - fever KW - porcine respiratory disease complex KW - PRDC N2 - Objective: To investigate the efficacy of acetylsalicylic acid (ASA) as an adjunct to antibiotic treatment of pigs with fever during an outbreak of porcine respiratory disease complex (PRDC).Materials and methods: The animals were divided into two groups. The experimental group received doxycycline hyclate and ASA in the drinking water for 5 consecutive days at doses of 10 mg per kg and 100 mg per kg of body weight, respectively, whereas the control group received only doxycycline hyclate (10 mg per kg). Clinical efficacy was investigated by comparing the synergistic or antagonistic effects of ASA administered with an antibiotic versus use of the antibiotic alone to reduce fever or clinical signs or both.Results: Results showed a significant decrease in fever in the group that received ASA and antibiotic versus the values observed in the group that received only antibiotic. No synergistic effect between ASA and doxycycline hyclate was observed to decrease respiratory signs.Implication: Acetylsalicylic acid is efficacious, at least to reduce fever, as an adjunct to antibacterial treatment of PRDC. ER -