TY - JOUR AU - Rapp-Gabrielson, VJ AU - Hoover, T AU - Sornsen, S TI - Effects of Mycoplasma hyopneumoniae vaccination in pigs co-infected with M hyopneumoniae and porcine circovirus type 2 T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2008/Jan// PY - 2008 VL - 16 M1 - 1 IS - 1 M2 - 16 SP - 16-26 L2 - https://www.aasv.org/shap/issues/v16n1/v16n1p16.htm UR - https://www.aasv.org/shap/abstracts/abstract.php?v16n1p16 L1 - https://www.aasv.org/shap/issues/v16n1/v16n1p16.pdf KW - swine KW - Mycoplasma hyopneumoniae KW - porcine circovirus type 2 KW - co-infection KW - postweaning multisystemic wasting syndrome KW - PCV KW - PMWS N2 - Objectives: To evaluate clinical and productionparameters in pigs vaccinated with commercially availableMycoplasma hyopneumoniae (M hyo) bacterins, then co-infectedwith M hyo and porcine circovirus type 2 (PCV2).Materials and methods: Weaned pigs (n = 296) were eachvaccinated with one of three M hyo bacterins or a placebo andchallenged 3 and 5 weeks after the second vaccination with M hyoand PCV2, respectively. A subset of pigs, necropsied 2 or 4 weeksafter PCV2 challenge, were evaluated for clinical signs, lesions,PCV2 serum levels, and M hyo in bronchial alveolar lavage fluids.Antibody titers to M hyo and PCV2 and average daily gain (ADG) weredetermined periodically during the trial. Estimated carcass valuewas determined at market weight.Results: In the placebo group, the challenge causedsevere respiratory disease associated with M hyo and PCV2. Therewas no evidence of vaccine-enhanced PCV2 associated disease, inthat the vaccine and placebo groups did not differ in PCV2 serumlevels, severity of PCV2 lesions, or incidence of PCV2-associateddisease. Vaccinated groups had lower lung lesion scores at necropsy2 weeks post challenge and higher body weights and ADG at the studyconclusion.Implications: When short-term clinical and long-termproduction parameters are evaluated, control of M hyo infection byM hyo vaccination is an important tool in reducing respiratorydisease and production losses in herds infected with both PCV2 andM hyo. Under the conditions of this study, M hyo vaccination doesnot enhance disease associated with PCV2 infection. ER -