Abstract:

Use of equine-origin antitoxins in piglets prior to exposure to mitigate the effects of Clostridium difficile infection – a pilot study

Alejandro Ramirez, DVM, MPH, PhD, Diplomate ACVPM; Eric W. Rowe, DVM, PhD; Paulo H. Arruda, DVM, MS; Darin M. Madson, DVM, PhD, Diplomate ACVP

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Administration to newborn pigs of an oral or intraperitoneal dose of equine-origin Clostridium difficile antitoxin 4 hours before orogastric inoculation with a swine-origin C difficile field isolate resulted in lower histopathology scores 72 hours post challenge than in pigs receiving no antitoxin (P < .05).

Keywords: Clostridium difficile, Clostridium difficile-associated disease, antitoxin, prevention

RIS citationCite as: Ramirez A, Rowe EW, Arruda PH, et al. Use of equine-origin antitoxins in piglets prior to exposure to mitigate the effects of Clostridium difficile infection – a pilot study. J Swine Health Prod 2014;22(1):29-32.

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