Abstract:

Impact of pH modifiers and drug exposure on the solubility of pharmaceutical products commonly administered through water delivery systems

Paul M. Dorr, DVM, PhD, MACE; Darin Madson, DVM; Spencer Wayne, DVM; Alan B. Scheidt, DVM, MS; Glen W. Almond, DVM, MSc, PhD

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Fifteen antimicrobial powders and aspirin were prepared according to label directions and evaluated for pH and temperature, settling after 5 days, and physical-chemical reactions when pairs of products were mixed. Many products changed state or precipitated when mixed with other products or when the pH was altered.

Keywords: medication, water soluble, pH

Cite as: Dorr PM, Madson D, Wayne S, et al. Impact of pH modifiers and drug exposure on the solubility of pharmaceutical products commonly administered through water delivery systems. J Swine Health Prod 2009;17(4):217-222.

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